Predictive role of SLC1A5 in neuroblastoma prognosis and immunotherapy.

ABSTRACT:

Background

Neuroblastoma, a prevalent extracranial solid tumor in pediatric patients, demonstrates significant clinical heterogeneity, ranging from spontaneous regression to aggressive metastatic disease. Despite advances in treatment, high-risk neuroblastoma remains associated with poor survival. SLC1A5, a key glutamine transporter, plays a dual role in promoting tumor growth and immune modulation. However, its contributions to neuroblastoma biology remain largely unexplored.

Methods

This study utilized clinical neuroblastoma samples from 20 patients and 1310 cases from four public datasets to investigate SLC1A5 expression, biological function, and prognostic significance. Differential expression, Kaplan-Meier survival analysis, gene set enrichment analysis, and weighted co

SUBMITTER: Cheng J 

PROVIDER: S-EPMC11773968 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature