Trajectories of general and central obesity beyond middle age in relation to late-life cognitive decline and dementia.

ABSTRACT:

Objective

The objective was to evaluate the longitudinal patterns of central and general obesity, identify their genetic and behavioral risk determinants, and investigate the association of distinct obesity trajectories beyond middle age with subsequent cognitive decline and the risk of developing dementia in late life.

Methods

Using a nationally representative, longitudinal, community-based cohort, we examined trajectory patterns of obesity over a 14-year span beyond middle age employing latent mixture modeling. We then evaluated their relationship with subsequent cognitive decline through linear mixed models and with the risk of developing dementia using Cox models, adjusting for confounding variables.

Results

Among the 4751 eligible participants (mean age, 58.7 [SD

SUBMITTER: Liang Z 

PROVIDER: S-EPMC11774005 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature