Interplay between genetic risk and built neighborhood conditions as predictor of BMI across the transition into adulthood.

ABSTRACT:

Objective

We examined BMI development across changes in the built environment during the transition from adolescence to young adulthood and explored the moderating role of genetic risk.

Methods

We used longitudinal data from individuals aged 16 to 25 years in the TRacking Adolescents' Individual Lives Survey (TRAILS) that we linked to built environment data for 2006, 2010, and 2016 from the Geoscience and Health Cohort Consortium (GECCO). We fitted a latent growth model of BMI and examined associations of changes in fast-food restaurant density and walkability with changes in BMI (n = 2735), as well as interactions of changes in fast-food restaurant density and walkability with genetic risk (n = 1676).

Results

Changes in fast-food restaurant density (e.g., Δ2010-2006:

SUBMITTER: de Roo M 

PROVIDER: S-EPMC11774011 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature