Perforin-2 is dispensable for host defense against <i>Aspergillus fumigatus</i> and <i>Candida albicans</i>.

ABSTRACT: Myeloid phagocytes are essential for antifungal immunity against pulmonary Aspergillus fumigatus and systemic Candida albicans infections. However, the molecular mechanisms underlying fungal clearance by phagocytes remain incompletely understood. In this study, we investigated the role of Perforin-2 (Mpeg1) in antifungal immunity. We found that Mpeg1^-/- mice generated on a mixed C57BL/6J-DBA/2 background exhibited enhanced survival, reduced lung fungal burden, and greater neutrophil fungal killing activity compared to wild-type C57BL/6J (B6) mice, suggesting that Perforin-2 may impair antifungal immune responses. However, when we compared Mpeg1^-/- mice with co-housed Mpeg^+/+ littermate controls, these differences we

SUBMITTER: Aufiero MA 

PROVIDER: S-EPMC11774031 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature