Skin-associated <i>Corynebacterium amycolatum</i> shares cobamides.

ABSTRACT: The underlying interactions that occur to maintain skin microbiome composition, function, and overall skin health are largely unknown. Often, these types of interactions are mediated by microbial metabolites. Cobamides, the vitamin B₁₂ family of cofactors, are essential for metabolism in many bacteria but are only synthesized by a fraction of prokaryotes, including certain skin-associated species. Therefore, we hypothesize that cobamide sharing mediates skin community dynamics. Preliminary work predicts that several skin-associated Corynebacterium species encode de novo cobamide biosynthesis and that their abundance is associated with skin microbiome diversity. Here, we show that commensal Corynebacterium amycolatum produces cobamides and that this synthesis

SUBMITTER: Swaney MH 

PROVIDER: S-EPMC11774034 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature