Small RNA CjNC110 regulates the activated methyl cycle to enable optimal chicken colonization by <i>Campylobacter jejuni</i>.

ABSTRACT: Post-transcriptional gene regulation by non-coding small RNAs (sRNAs) is critical for colonization and survival of enteric pathogens, including the zoonotic pathogen Campylobacter jejuni. In this study, we utilized C. jejuni IA3902 (a representative isolate of the sheep abortion clone) and C. jejuni W7 (a highly motile variant of NCTC 11168, a human gastroenteritis strain) to further investigate regulation by sRNA CjNC110. Both motility and autoagglutination ability were confirmed to be phenotypes of conserved regulation by CjNC110. However, we demonstrated that W7∆CjNC110 does not change chicken colonization levels compared to W7 wild type, directly contrasting IA3902∆CjNC110, which had decreased colonization ability. Subsequently, we determined strain-specific phenot

SUBMITTER: Ruddell B 

PROVIDER: S-EPMC11774046 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature