Comparative analysis of the human microbiome from four different regions of China and machine learning-based geographical inference.

ABSTRACT: The human microbiome, the community of microorganisms that reside on and inside the human body, is critically important for health and disease. However, it is influenced by various factors and may vary among individuals residing in distinct geographic regions. In this study, 220 samples, consisting of sterile swabs from palmar skin and oral and nasal cavities were collected from Chinese Han individuals living in Shanghai, Chifeng, Kunming, and Urumqi, representing the geographic regions of east, northeast, southwest, and northwest China. The full-length 16S rRNA gene of the microbiota in each sample was sequenced using the PacBio single-molecule real-time sequencing platform, followed by clustering the sequences into operational taxonomic units (OTUs). The analysis revealed significant dif

SUBMITTER: Lei Y 

PROVIDER: S-EPMC11774049 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature