Joint Analysis of Multiple Omics to Describe the Biological Characteristics of Resistant Hypertension.

ABSTRACT: Resistant hypertension (RH) may cause severe target organ damage and poses significant challenges in the field of hypertension prevention and treatment. Mining biological characteristics is crucial for exploring the pathogenesis of RH and for early diagnosis and treatment. Although several single-omics studies have been conducted on RH, its complex pathogenesis has only been partially elucidated. In this study, metabolomics, proteomics, and transcriptomics were jointly analyzed in healthy subjects and patients with hypertension and RH. The multi-omics analysis found that differential substances of RH were enriched in the HIF-1 signaling pathway and that differential substances such as ascorbic acid, reduced glutathione (GSH), choline, citric acid, transferrin receptor (TfR), Egl-9 family h

SUBMITTER: Wang S 

PROVIDER: S-EPMC11774085 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature