Exploring WNT2 polymorphisms in comitant strabismus: A genetic association study.

ABSTRACT:

Background

Strabismus is a complex oculomotor condition characterized by a misalignment of the visual axis. The genetics of strabismus are poorly defined although a few candidate genes have been identified, among which is the WNT2 gene. Our study was designed to assess the association of single nucleotide polymorphisms (SNPs) of WNT2 in Pakistani strabismus patients.

Methods

A total of six SNPs, three intronic and three in the 3́ untranslated region, were screened in the current study. Logistic regression was performed using a dominant, recessive and additive model to determine the association of SNPs with strabismus and its clinical subtypes: esotropia and exotropia. Furthermore, haplotype analysis was performed.

Results

Regression analysis revealed an association of

SUBMITTER: Zehra Z 

PROVIDER: S-EPMC11774097 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature