Spontaneously Immortalised Nonhuman Primate Muller Glia Cell Lines as Source to Explore Retinal Reprogramming Mechanisms for Cell Therapies.

ABSTRACT: Cell replacement therapies for ocular diseases characterised by photoreceptors degeneration are challenging due to poor primary cell survival in culture. A stable retinal cell source to replace lost photoreceptors holds promise. Müller glia cells play a pivotal role in retinal homoeostasis by providing metabolic and structural support to retinal neurons, preventing aberrant photoreceptors migration, and facilitating safe glutamate uptake. In fish and amphibians, injured retinas regenerate due to Müller-like glial stem cells, a phenomenon absent in the mammalian retina for unknown reasons. Research on Müller cells has been complex due to difficulties in obtaining pure cell population and their rapid de-differentiation in culture. While various Müller glia cell lines from human and rats are

SUBMITTER: Salman A 

PROVIDER: S-EPMC11774137 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature