Pre-treatment subjective sleep quality as a predictive biomarker of tDCS effects in preclinical Alzheimer's disease patients: Secondary analysis of a randomised clinical trial.

ABSTRACT:

Background

Despite transcranial direct current stimulation (tDCS) has demonstrated encouraging potential for modulating the circadian rhythm, little is known about how well and sustainably tDCS might improve the subjective sleep quality in older adults. This study sought to determine how tDCS affected sleep quality and cognition, as well as how well pre-treatment sleep quality predicted tDCS effects on domain-specific cognitive functions in patients with mild neurocognitive disorder due to Alzheimer's disease (NCD-AD).

Methods

This clinical trial aimed to compare the effectiveness of tDCS and cognitive training in mild NCD-AD patients (n =  201). Over the course of four weeks, patients were randomized to receive either tDCS plus working memory training, or sham tDCS plus wor

SUBMITTER: Lu H 

PROVIDER: S-EPMC11774347 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature