Pro-cognitive restoration of experience-dependent parvalbumin inhibitory neuron plasticity in neurodevelopmental disorders.

ABSTRACT: The hippocampus forms memories of our experiences by registering processed sensory information in coactive populations of excitatory principal cells or ensembles^1-3. Fast-spiking parvalbumin-expressing inhibitory neurons (PV INs) in the dentate gyrus (DG)-CA3/CA2 circuit contribute to memory encoding by exerting precise temporal control of excitatory principal cell activity through mossy fiber-dependent feed-forward inhibition^4-13. PV INs respond to input-specific information by coordinating changes in their intrinsic excitability, input-output synaptic-connectivity, synaptic-physiology and synaptic-plasticity^9,13-17, referred to here as experience-dependent PV IN plasticity, to influence hippocampal functions. PV IN impairments in early life, when neural c

SUBMITTER: Shih YT 

PROVIDER: S-EPMC11774442 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature