Proteomics-based aging clocks in midlife and late-life and risk of dementia.

ABSTRACT:

Background

Biological age can be quantified by composite proteomic scores, called aging clocks. We investigated whether biological age acceleration (a discrepancy between chronological and biological age) in midlife and late-life is associated with cognitive function and risk of dementia.

Methods

We used two population-based cohort studies: Atherosclerosis Risk in Communities (ARIC) Study and Multi-Ethnic Study of Atherosclerosis (MESA). Proteomics-based aging clocks (PACs) were created in ARIC at midlife (mean age: 58 years, n=11,758) and late-life (mean age: 77 years, n=4,934) using elastic net regression models in two-thirds of dementia-free participants and validated in the remaining one-third of participants. Age acceleration (AA) was calculated as residuals after regre

SUBMITTER: Sedaghat S 

PROVIDER: S-EPMC11774457 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature