Influence of Acquisition Parameters on Silver Sulfide Nanoparticle Contrast in Photon-Counting Digital Mammography: A Phantom Study.

ABSTRACT: Photon-counting mammography is an emerging modality that allows for spectral imaging and provides a differentiation of material compositions. The development of photon-counting mammography-specific contrast agents has yet to be explored. In this study, the contrast, sensitivity, and organ dose between silver sulfide nanoparticles (Ag₂S-NPs) and a clinically approved iodinated agent (iopamidol) were investigated using a contrast-embedded gradient ramp phantom and a prototype scanner. For a given agent, the signal intensity increased with concentration, tube voltage (kV), and high bin fraction, while remaining constant with the tube current exposure time product (mAs). Moreover, Ag₂S-NPs produced significantly stronger contrast and improved sensitivity compared to iodin

SUBMITTER: Hsu JC 

PROVIDER: S-EPMC11774497 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature