Narrative review of targetable features of pediatric acute myeloid leukemia from molecular and metabolic perspectives.

ABSTRACT:

Background and objective

Unlike the majority of pediatric leukemia patients, young patients with acute myeloid leukemia (AML) have not seen significant improvement in treatment outcomes. This is frequently attributed to the heterogeneity of this malignancy in terms of its mutations and molecularly defined categories. In adult versus pediatric cases of AML, the heterogeneity is preserved, although there are key differences in the incidence of gene mutations, chromosomal translocations, and other molecular features. Current treatment strategies consider broader cellular features of AML, such as altered metabolic and anti-apoptotic properties, and many of these are common across pediatric and adult AML.

Methods

A narrative review was conducted to compile literature regarding mo

SUBMITTER: Trabal AM 

PROVIDER: S-EPMC11774499 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature