Epidemiology of Epstein-Barr Virus Chronic High Viral Load in Kidney Transplant Recipients.

ABSTRACT:

Background

Epstein-Barr virus (EBV) chronic high viral load (CHVL) may be defined by >16 000 copies/mL whole blood or >200 copies/10⁵ peripheral blood mononuclear cells in >50% samples exceeding 6 mo. EBV CHVL has only been characterized in a few small pediatric studies, with heterogeneous results and unclear clinical significance.

Methods

This single-center observational study evaluated adult and pediatric kidney transplant recipients transplanted between 2010 and 2021 on tacrolimus/mycophenolate-based/prednisone immunosuppression. The primary outcome was EBV CHVL prevalence. Secondary outcomes included recipient characteristics, DNAemia kinetics, and posttransplant lymphoproliferative disorder (PTLD) in recipients with EBV CHVL versus low-grade DNAemia or no DNA

SUBMITTER: Rampersad C 

PROVIDER: S-EPMC11774561 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature