Genetically predicted brain cortical structure mediates the causality between insulin resistance and cognitive impairment.

ABSTRACT:

Background

Insulin resistance is tightly related to cognition; however, the causal association between them remains a matter of debate. Our investigation aims to establish the causal relationship and direction between insulin resistance and cognition, while also quantifying the mediating role of brain cortical structure in this association.

Methods

The publicly available data sources for insulin resistance (fasting insulin, homeostasis model assessment beta-cell function and homeostasis model assessment insulin resistance, proinsulin), brain cortical structure, and cognitive phenotypes (visual memory, reaction time) were obtained from the MAGIC, ENIGMA, and UK Biobank datasets, respectively. We first conducted a bidirectional two-sample Mendelian randomization (MR) analysis

SUBMITTER: Huang C 

PROVIDER: S-EPMC11774689 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature