Spinal cord injury enhances lung inflammation and exacerbates immune response following exposure to LPS.

ABSTRACT:

Introduction

The severity of spinal cord injury (SCI) is closely tied to pulmonary function, especially in cases of higher SCI levels. Despite this connection, the underlying pathological mechanisms in the lungs post-SCI are not well understood. Previous research has established a connection between disrupted sympathetic regulation and splenocyte apoptosis in high thoracic SCI, leading to pulmonary dysfunction. The aim of this study was to investigate whether mice with low-level SCI exhibit increased susceptibility to acute lung injury by eliciting systemic inflammatory responses that operate independently of the sympathetic nervous system.

Methods

Here, we employed T9 contusion SCI and exposed mice to aerosolized lipopolysaccharide (LPS) to simulate lung inflammation associ

SUBMITTER: Berk BC 

PROVIDER: S-EPMC11774706 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature