Gut microbiota, metabolites, and cytokines in relation to the risk of prostate cancer in the Asian population.

ABSTRACT:

Purpose

Studies have shown that gut microbiota is involved in the tumorigenesis and development of prostate cancer. We aimed to perform a comprehensive analysis of causal associations of gut microbiota, metabolites, and cytokines with prostate cancer in the Asian population.

Patients and methods

Genome-wide association study (GWAS) summary datasets were collected from the public databases. There were 418 bacterial traits, 452 metabolites, 91 cytokines, 5408 cases of prostate cancer from East Asia, and 109,347 controls included. Mendelian randomization (MR) analyses were performed to investigate their causal relationships. Sensitivity analyses were conducted to test the reliability of MR results. Furthermore, the FinnGen database was used to assess the generalizability of our

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11774728 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature