Upregulation of HSP90α in the lungs and circulation in sarcoidosis.

ABSTRACT:

Background

Sarcoidosis is a systemic granulomatous disease of unknown cause. Natural improvement with favorable outcome is common, but a significant number of patients present with difficult to manage and progressive disease. The identification of biomarkers associated with disease activity and progression is warranted. Extracellular heat shock protein 90 (HSP90) α is a signaling molecule released by cells that induces proinflammatory signaling through interaction with certain receptors, such as lipoprotein receptor-related protein 1.

Materials and methods

HSP90α protein expression in lung tissues derived from patients diagnosed with sarcoidosis and control subjects was assessed by immunohistochemistry. Serum HSP90α concentration was measured in sarcoidosis patients a

SUBMITTER: Isshiki T 

PROVIDER: S-EPMC11774731 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature