Differences in the intrahepatic expression of immune checkpoint molecules on T cells and natural killer cells in chronic HBV patients.

ABSTRACT:

Background

Patients with chronic hepatitis B virus (HBV) infection are characterized by impaired immune response that fails to eliminate HBV. Immune checkpoint molecules (ICMs) control the amplitude of the activation and function of immune cells, which makes them the key regulators of immune response.

Methods

We performed a multiparametric flow cytometry analysis of ICMs and determined their expression on intrahepatic lymphocyte subsets in untreated and treated patients with HBV in comparison with non-pathological liver tissue.

Results

The liver of untreated HBV patients exhibited a high accumulation of PD-1⁺CD8⁺ T cells, while the frequencies of 4-1BB⁺ T cells, 4-1BB⁺ natural killer (NK) cells, and TIM-3⁺CD8

SUBMITTER: Dumolard L 

PROVIDER: S-EPMC11774737 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature