Predicting patient outcomes with gene-expression biomarkers from colorectal cancer organoids and cell lines.

ABSTRACT:

Introduction

Colorectal cancer (CRC) is characterized by an extremely high mortality rate, mainly caused by the high metastatic potential of this type of cancer. To date, chemotherapy remains the backbone of the treatment of metastatic colorectal cancer. Three main chemotherapeutic drugs used for the treatment of metastatic colorectal cancer are 5-fluorouracil, oxaliplatin and irinotecan which is metabolized to an active compound SN-38. The main goal of this study was to find the genes connected to the resistance to the aforementioned drugs and to construct a predictive gene expression-based classifier to separate responders and non-responders.

Methods

In this study, we analyzed gene expression profiles of seven patient-derived CRC organoids and performed correlation analyse

SUBMITTER: Razumovskaya A 

PROVIDER: S-EPMC11774744 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature