Anti-melanogenic effects of hydroxyethyl chrysin through the inhibition of tyrosinase activity: In vitro and in silico approaches.

ABSTRACT: The suppression of tyrosinase (TYR), a key enzyme in melanogenesis, has been suggested as an effective strategy for preventing melanin accumulation. We previously discovered the novel chrysin derivative hydroxyethyl chrysin (HE-chrysin) through an irradiation technique, which exerted higher anti-inflammatory and anti-cancer activities than original chrysin. In the present study, we explored whether HE-chrysin has antioxidant and anti-melanogenic capacity using in vitro B16F10 murine melanoma cells and in silico molecular docking. HE-chrysin exhibited enhanced antioxidant capacity in DPPH, ABTS, and FRAP assays, and it decreased cellular H₂O₂-stimulated reactive oxygen species levels in comparison to original chrysin. At 2.5 μM, HE-chrysin reduced 3-isobu

SUBMITTER: Lee Y 

PROVIDER: S-EPMC11774776 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature