Clinical features and prognostic factors of pediatric Langerhans cell histiocytosis: a single-center retrospective study.

ABSTRACT:

Purpose

To retrospectively evaluate the clinical features and prognostic factors of pediatric LCH patients treated in a single center of China.

Methods

Pediatric LCH cases were treated following the SD-LCH protocol at the Affiliated Provincial Hospital of Shandong First Medical University in Jinan, China. An analysis was conducted on 82 recently identified LCH cases to retrospectively evaluate the initial symptoms, therapeutic alternatives, and extended results. Follow-ups were conducted until July 31, 2023.

Results

The median age at diagnosis was 2 (0.25-12) years. 42 (51.2%) were SS-LCH, and 40 (48.8%) were MS-LCH. The most common organ involved was bone (82.9%). Over the 16-year follow-up period, the 5-year EFS and OS rates were 75.2 ± 5% and 90.9 ± 3.3%, respectiv

SUBMITTER: Lu Y 

PROVIDER: S-EPMC11774849 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature