Dexmedetomidine improves clinical outcomes in sepsis-induced myocardial injury: a retrospective cohort study.

ABSTRACT:

Background

The efficacy of dexmedetomidine (DEX) in treating sepsis-induced myocardial injury (SIMI) remains unclear. In this study, we explored the relationship between DEX use and clinical outcomes of patients with SIMI, focusing on the dosage and treatment duration.

Methods

In this retrospective cohort analysis, we identified patients with SIMI from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database and categorized them into the DEX and non-DEX groups based on intensive care unit treatment. The baseline bias was reduced through propensity score matching (PSM). The primary outcome was 28-day mortality, whereas the secondary outcomes were in-hospital mortality and mortality rates at 7 days, 90 days, and 1 year. The association between DEX use and in-hosp

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11774859 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature