MicroRNAs signatures as potential molecular markers in mild cognitive impairment: a meta-analysis.

ABSTRACT: Mild cognitive impairment (MCI) is characterized by a decline in cognitive functioning without significant interference in daily activities. Its high heterogeneity and elevated conversion rate to dementia pose challenges for accurate diagnosis and monitoring, highlighting the urgent need to identify methodologies focused on the early detection and intervention of MCI. Due to their biological characteristics, microRNAs (miRNAs) are potential candidates as non-invasive molecular markers for the identification and assessment of MCI progression. Therefore, in this study, we conducted a meta-analysis to identify the miRNAs commonly deregulated in MCI, focusing on expression profiles in plasma, serum, and extracellular vesicle samples. Our analysis identified eight upregulated miRNAs, including

SUBMITTER: Vargas-Rondon N 

PROVIDER: S-EPMC11774935 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature