The effect of nightly use of 150 mg cannabidiol on daytime neurocognitive performance in primary insomnia: a randomized controlled pilot trial.

ABSTRACT:

Rationale

Cannabidiol (CBD) is increasingly used as a sleep aid for insomnia; yet neurocognitive and subjective state effects following daily therapeutic use are unclear.

Objectives

To measure the effect of daily CBD use on neurocognitive performance and daily subjective mood in a population with primary insomnia.

Methods

This study used a randomized, placebo-controlled, parallel design incorporating a single-blind placebo run-in week followed by a two-week double-blind dosing period, during which participants consumed 150 mg CBD (N = 15) or placebo (N = 15) sublingually 60-minutes daily before bed. Attention, executive function, reasoning, information processing, working and episodic memory were assessed using the CogPro system at the beginning of the placebo run-in,

SUBMITTER: Narayan AJ 

PROVIDER: S-EPMC11774964 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature