Efficacy and safety of hydroxyurea therapy on patients with <i>β</i>-thalassemia: a systematic review and meta-analysis.

ABSTRACT:

Objective

Our aim is to review the safety and efficacy of hydroxyurea (HU) on β-thalassemia patients.

Methods

Studies that evaluated the safety and efficacy of HU on β-thalassemia patients were searched in Pub-Med, Cochrane Databases, Web of Science, China-Biology-Medicine, CNKI, Embase, VIP, and WanFang data. The proportions of response rate (RR) (50% fall in transfusion need in transfusion-dependent β-thalassemia patients, or 1 g/dL elevate in hemoglobin (Hb) levels in transfusion-independent β-thalassemia patients) and good RR (transfusion-free in transfusion-dependent β-thalassemia patients or 2 g/dL elevate in Hb levels in transfusion-independent β-thalassemia patients) were utilized to evaluate the effect size (ES). The secondary outcomes we

SUBMITTER: Huang T 

PROVIDER: S-EPMC11774989 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature