Effects of zuranolone on next-day simulated driving in healthy adults.

ABSTRACT:

Rationale

Zuranolone is an oral positive allosteric modulator of GABA_A receptors. Due to its central nervous system (CNS) activity, zuranolone may impact activities requiring complex cognition, including driving.

Objective

Evaluate the effect of zuranolone on simulated driving performance.

Methods

In this randomized, double-blind, active- and placebo-controlled, four-period crossover study, treatments included once-nightly zuranolone 50 mg on days 1-7, zuranolone 50 mg on days 1-6 and zuranolone 100 mg on day 7, zopiclone 7.5 mg on days 1 and 7, and placebo on days 1-7. Driving was assessed using a validated simulator. Primary endpoint was standard deviation of lateral position (SDLP), evaluated 9 h post-dose on days 2 and 8. Secondary endpoints included ad

SUBMITTER: Dunbar J 

PROVIDER: S-EPMC11775036 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature