Multimodal creativity assessments following acute and sustained microdosing of lysergic acid diethylamide.

ABSTRACT:

Introduction

Enhanced creativity is often cited as an effect of microdosing (taking repeated low doses of a psychedelic drug). There have been recent efforts to validate the reported effects of microdosing, however creativity remains a difficult construct to quantify.

Objectives

The current study aimed to assess microdosing's effects on creativity using a multimodal battery of tests as part of a randomised controlled trial of microdosing lysergic acid diethylamide (LSD).

Methods

Eighty healthy adult males were given 10 µg doses of LSD or placebo every third day for six weeks (14 total doses). Creativity tasks were administered at a drug-free baseline session, at a first dosing session during the acute phase of the drug's effects, and in a drug-free final session follo

SUBMITTER: Murphy RJ 

PROVIDER: S-EPMC11775047 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature