Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype.

ABSTRACT: Macrophage plasticity is critical for maintaining immune function and developing solid tumors; however, the macrophage polarization mechanism remains incompletely understood. Our findings reveal that Mg²⁺ entry through distinct plasma membrane channels is critical to macrophage plasticity. Naïve macrophages displayed a previously unidentified Mg²⁺ dependent current, and TRPM7-like activity, which modulates its survival. Significantly, in M1 macrophages, Mg²⁺ entry is facilitated by a novel Mg²-dependent current that relies on extracellular Mg²⁺, which was crucial for activating iNOS/NFκB pathways and cellular bioenergetics, which drives pro-inflammatory cytokines. Conversely, in M2 macrophages, Mg²⁺ entry occurs primarily through TRPM7

SUBMITTER: Nascimento Da Conceicao V 

PROVIDER: S-EPMC11775176 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature