Homocysteine, neurodegenerative biomarkers, and APOE ε4 in neurodegenerative diseases.

ABSTRACT:

Introduction

Elevated plasma homocysteine (Hcy) is associated with an increased risk of developing neurodegenerative diseases; however, its relationship with the apolipoprotein E (APOE) ε4 allele has not been well characterized.

Methods

Participants clinically diagnosed with Alzheimer's disease or mild cognitive impairment (AD/MCI), frontotemporal dementia, Parkinson's disease, or cerebrovascular disease were stratified by the presence of the APOE ε4 allele. Volumetric magnetic resonance imaging, plasma amyloid/tau/neurodegeneration biomarkers, and cognitive performance were quantified.

Results

Across all diagnostic groups, Hcy was associated with lower brain parenchymal fraction and greater neurofilament light chain in APOE ε4 non-carriers only. In AD/MCI, Hcy was as

SUBMITTER: Lin WZ 

PROVIDER: S-EPMC11775453 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature