APOE ε4-associated heterogeneity of neuroimaging biomarkers across the Alzheimer's disease continuum.

ABSTRACT:

Introduction

While the role of apolipoprotein E (APOE) ε4 in Alzheimer's disease (AD) susceptibility has been studied extensively, much less is known about the differences in disease presentation in APOE ε4 carriers versus non-carriers.

Methods

To help elucidate these differences, we performed a broad analysis comparing the regional levels of six different neuroimaging biomarkers in the brains of APOE ε4 carriers versus non-carriers who participated in the Alzheimer's Disease Neuroimaging Initiative (ADNI).

Results

We observed significant APOE ε4-associated heterogeneity in regional amyloid beta deposition, tau accumulation, glucose uptake, brain volume, cerebral blood flow, and white matter hyperintensities within each AD diagnostic group. We also observed important

SUBMITTER: Mares J 

PROVIDER: S-EPMC11775459 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature