Drug-induced heart failure: a real-world pharmacovigilance study using the FDA adverse event reporting system database.

ABSTRACT:

Objective

Although there are certain drug categories associated with heart failure (HF), most of the associated risks are unclear. We investigated the top drugs associated with HF and acute HF (AHF) reported in the FDA Adverse Event Reporting System (FAERS).

Methods

We reviewed publicly available FAERS databases from 2004 to 2023. Using the search terms "cardiac failure" or "cardiac failure acute" and classifying cases by drug name, we processed and analyzed drug reports related to HF or AHF.

Results

From 2004 to 2023, 17,379,609 adverse drug events were reported by FAERS, of which 240,050 (1.38%) were reported as HF. Among those with HF, the male-to-female ratio was 0.94% and 52.37% were >65 years old; 46.2% were from the United States. There were 5,971 patients with

SUBMITTER: Huang Y 

PROVIDER: S-EPMC11775474 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature