Non-Invasive Photoacoustic Cerebrovascular Monitoring of Early-Stage Ischemic Strokes In Vivo.

ABSTRACT: Early-stage stroke monitoring enables timely intervention that is crucial to minimizing neuronal damage and increasing the extent of recovery. By monitoring collateral circulation and neovascularization after ischemic stroke, the natural recovery process can be better understood, optimize further treatment strategies, and improve the prognosis. Photoacoustic computed tomography (PACT), a non-invasive imaging modality that captures multiparametric high-resolution images of vessel structures, is well suited for evaluating cerebrovascular structures and their function. Here 3D multiparametric transcranial PACT is implemented to monitor the early stage of a photothrombotic (PT)-stroke model in living rats. New vessels in the PT-induced region are successfully observed using PACT, and these obs

SUBMITTER: Kim J 

PROVIDER: S-EPMC11775540 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature