Microwave Ablation Combined with Flt3L Provokes Tumor-Specific Memory CD8⁺ T Cells-Mediated Antitumor Immunity in Response to PD-1 Blockade.

ABSTRACT: For medically inoperable non-small cell lung cancer, microwave ablation (MWA) represents a super minimally invasive alternative treatment. However, tumor recurrence remains a concern. Here, it is demonstrated that the combination of MWA with Flt3L significantly inhibits tumor recurrence by CD8⁺ central memory T (T_CM)-like cell-dependent antitumor immune responses within the tumor-draining lymph nodes (TdLN). TdLN-T_CM-like cells encompassed both tumor-specific memory T (T_TSM) and progenitor-exhausted T (T_PEX) cells. The expansion of these cells markedly altered the differentiation of exhausted T cells within the tumor microenvironment (TME). T_PEX predominantly differentiated into transitory effector-like exhausted T cells (T<

SUBMITTER: Wang M 

PROVIDER: S-EPMC11775548 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature