Antibiotic duration for common bacterial infections-a systematic review.

ABSTRACT:

Background

Reducing antibiotic duration is a key stewardship intervention to mitigate antimicrobial resistance (AMR). We examined current evidence informing antibiotic duration for common bacterial infections to identify any gaps in terms of settings, patient populations and infectious conditions. Trial methodologies were assessed to identify areas for improvement.

Methods

MEDLINE and Embase were searched up to July 2024 for randomized trials comparing antibiotic durations in hospital and community settings (PROSPERO 2021, CRD42021276209). A narrative synthesis of the results was performed with a review on the major guidelines published by IDSA, NICE, WHO and other international societies to assess the impact of these trials on practice guidance.

Results

Out of 315 st

SUBMITTER: Mo Y 

PROVIDER: S-EPMC11775593 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature