Targeting Ribosome Biogenesis for Cancer Therapy with Oral Platinum Complexes.

ABSTRACT: Cancer cells often upregulate ribosome biogenesis to meet increased protein synthesis demands for rapid proliferation; therefore, targeting ribosome biogenesis has emerged as a promising cancer therapeutic strategy. Herein, we introduce two Pt complexes, ataluren monosubstituted platinum(IV) (SPA, formula: c,c,t,-[Pt(NH₃)₂Cl₂(OH)(C₁₅H₈FN₂O₃)], where C₁₅H₈FN₂O₃ = ataluren) and ataluren bisubstituted platinum(IV) complex (DPA, formula: c,c,t,-[Pt(NH₃)₂Cl₂(C₁₅H₈FN₂O₃)₂], where C₁₅H₈FN₂O₃ = ataluren), which effectively suppress ribosome biogenes

SUBMITTER: Song D 

PROVIDER: S-EPMC11775699 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature