Pattern Separation and Pattern Completion Within the Hippocampal Circuit During Naturalistic Stimuli.

ABSTRACT: Pattern separation and pattern completion in the hippocampus play a critical role in episodic learning and memory. However, there is limited empirical evidence supporting the role of the hippocampal circuit in these processes during complex continuous experiences. In this study, we analyzed high-resolution fMRI data from the "Forrest Gump" open-access dataset (16 participants) using a sliding-window temporal autocorrelation approach to investigate whether the canonical hippocampal circuit (DG-CA3-CA1-SUB) shows evidence consistent with the occurrence of pattern separation or pattern completion during a naturalistic audio movie task. Our results revealed that when processing continuous naturalistic stimuli, the DG-CA3 pair exhibited evidence consistent with the occurrence of the pattern sep

SUBMITTER: Sun L 

PROVIDER: S-EPMC11775762 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature