Neural correlates of systemic lidocaine administration in healthy adults measured by functional MRI: a single arm open label study.

ABSTRACT:

Introduction

Intravenous lidocaine is increasingly used as a nonopioid analgesic, but how it acts in the brain is incompletely understood. We conducted a functional MRI study of pain response, resting connectivity, and cognitive task performance in volunteers to elucidate the effects of lidocaine at the brain-systems level.

Methods

We enrolled 27 adults (age 22-55 yr) in this single-arm, open-label study. Pain response task and resting-state functional MRI scans at 3 T were obtained at baseline and then with a constant effect-site concentration of lidocaine. Electric nerve stimulation, titrated in advance to 7/10 intensity, was used for the pain task (five times every 10 s). Group-level differences in pain task-evoked responses (primary outcome, focused on the insula) and in

SUBMITTER: Vogt KM 

PROVIDER: S-EPMC11775839 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature