Preoperative estimated glomerular filtration rate to predict cardiac events in major noncardiac surgery: a secondary analysis of two large international studies.

ABSTRACT:

Background

Optimised use of kidney function information might improve cardiac risk prediction in noncardiac surgery.

Methods

In 35,815 patients from the VISION cohort study and 9219 patients from the POISE-2 trial who were ≥45 yr old and underwent nonurgent inpatient noncardiac surgery, we examined (by age and sex) the association between continuous nonlinear preoperative estimated glomerular filtration rate (eGFR) and the composite of myocardial injury after noncardiac surgery, nonfatal cardiac arrest, or death owing to a cardiac cause within 30 days after surgery. We estimated contributions of predictive information, C-statistic, and net benefit from eGFR and other common patient and surgical characteristics to large multivariable models.

Results

The primary composi

SUBMITTER: Roshanov PS 

PROVIDER: S-EPMC11775841 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature