Impact of adverse childhood experiences on analgesia-related outcomes: a systematic review.

ABSTRACT:

Background

There is well-established evidence linking adverse childhood experiences (ACEs) and chronic pain in adulthood. It is less clear how ACE exposure might influence the response to chronic pain treatment. In this systematic review, we synthesise the literature assessing the impact of ACE exposure on outcomes relating to the use, benefits, and harms of analgesic medications (analgesia-related outcomes).

Methods

We searched seven databases from inception to September 26, 2023, for studies investigating adverse events in childhood (<18 yr) and any analgesia-related outcome during adulthood (≥18 yr). Title/abstract screening, full-text review, data extraction, and risk of bias assessment were performed independently by two authors. Given the high degree of study heterogen

SUBMITTER: Senaratne DNS 

PROVIDER: S-EPMC11775844 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature