Catalytic Reductive Homocoupling of Benzyl Chlorides Enabled by Zirconocene and Photoredox Catalysis.

ABSTRACT: The bibenzyl skeleton is prevalent in numerous natural products and other biologically active compounds. Radical homocoupling provides a straightforward approach for synthesizing bibenzyls in a single step with the reductive homocoupling of benzyl halides undergoing extensive development. Unlike benzyl bromides and other tailored precursors used in visible-light-mediated homocoupling, benzyl chlorides offer greater abundance and chemical stability. Nevertheless, achieving chemoselective cleavage of the C-Cl bond poses significant challenges, with only a limited number of studies reported to date. Herein, we demonstrate a catalytic reductive homocoupling of benzyl chlorides facilitated by zirconocene and photoredox catalysis. This cooperative catalytic system promotes C-Cl bond cleavage in

SUBMITTER: Tajima R 

PROVIDER: S-EPMC11775857 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature