Water-Soluble Mn(III)-Porphyrins with High Relaxivity and Photosensitization.

ABSTRACT: Three water-soluble Mn(III)-porphyrin complexes with cationic pyridyl side groups bearing COOH- or OH-terminated carbon chains in the meta or para positions have been synthesized as probes for both magnetic resonance imaging (MRI) and photodynamic therapy (PDT). The complexes Mn-1, Mn-2, and Mn-3 are highly water-soluble, and their relaxivities range between 10 and 15 mM^-1 s^-1, at 20-80 MHz and 298 K, 2-3 times higher than that of commercial Gd(III)-based agents. The complexes containing carboxylate (Mn-2) or alcoholic (Mn-3) side chains in the para position are endowed with higher relaxivities and have also shown efficient photoinduced DNA cleavage and singlet oxygen (¹O₂) generation. Mn-3 with stronger

SUBMITTER: Nemeth T 

PROVIDER: S-EPMC11775858 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature