HIV-1 drug resistance and genetic transmission networks among patients with sexually transmitted HIV in Ningxia, China.

ABSTRACT:

Background

Over the past decade, sexual transmission has become a dominant source of new HIV-1 infection in China. However, very few studies have been conducted to characterize the two sexual transmissions, homosexual and heterosexual transmission. This study was conducted to better understand the relationship between genotypes, drug resistance, and molecular transmission networks in two groups of sexually transmitted HIV-1 in Ningxia, China.

Methods

Plasma samples were collected from sexually transmitted HIV/AIDS patients in Ningxia between 2020 and 2021 for RNA extraction followed by HIV-1 genome sequencing, genotype and drug resistance analyses. The TN93 model in HyPhy2.2.4 with 1.25% as the threshold, was used to calculate the gene distance, and Cytoscape3.7.0 was used t

SUBMITTER: Pei J 

PROVIDER: S-EPMC11775904 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature