Targeting the Neuro-vascular Presynaptic Signalling in STROKE: Evidence and Therapeutic Implications.

ABSTRACT:

Background

Stroke is one of the leading causes of death and long-term adult disability worldwide. Stroke causes neurodegeneration and impairs synaptic function. Understanding the role of synaptic proteins and associated signalling pathways in stroke pathology could offer insights into therapeutic approaches as well as improving rehabilitation-related treatment regimes.

Purpose

The current study aims to analyse synaptic transcriptome changes in acute and long-term post-stroke (1 day, 7 day timepoints), especially focusing on pre- and postsynaptic genes.

Methods

We performed data mining of the recent mRNA sequence from isolated mouse brain micro-vessels (MBMVs) after transient middle cerebral artery occlusion (tMCAO) stroke model. Using the SynGO (Synaptic Gene Ontologi

SUBMITTER: Maikap S 

PROVIDER: S-EPMC11775937 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature