Identification of clinical subgroups in anti-SRP positive immune-mediated necrotizing myopathy patients using cluster analysis.

ABSTRACT:

Background

Anti-signal recognition particle immune-mediated necrotizing myopathy (anti-SRP IMNM) is a rare autoimmune disorder characterized by muscle weakness and necrosis. Identifying clinical subgroups within this patient population could facilitate the management of the disease.

Objectives

To identify distinct clinical subgroups of anti-SRP IMNM patients.

Design

A retrospective study was conducted on anti-SRP IMNM patients treated at West China Hospital of Sichuan University between January 2010 and October 2023.

Methods

Clinical data were collected. Unsupervised cluster analysis was conducted to classify patients into distinct subgroups based on their clinical features. Statistical analyses were performed to compare the clinical characteristics and outcome

SUBMITTER: Cui B 

PROVIDER: S-EPMC11775970 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature