Prophylactic clemastine treatment improves influenza A virus-induced cognitive dysfunction in mice.

ABSTRACT: Respiratory infection by influenza A virus (IAV) is known to cause systemic inflammation, neuroinflammation, and cognitive impairment. We previously found that experimental infection with IAV affected oligodendrocyte homeostasis, which was associated with altered expression of genes involved in myelin maintenance as well as the lipidome. In this study, we sought to determine if clemastine, an antihistamine with myelin promoting properties, could reverse the effects of IAV on oligodendrocyte (OL) specific genes, as well as mitigate infection-induced cognitive impairment. Male and female C57BL/6J mice were randomized into experimental groups based on clemastine treatment, infection, and sex. Treatment with vehicle or clemastine (10 mg/kg/d) commenced seven days prior to inoculation with eith

SUBMITTER: Tingling JD 

PROVIDER: S-EPMC11776086 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature