Decarboxylase mediated oxalic acid metabolism is important to antioxidation and detoxification rather than pathogenicity in <i>Magnaporthe oryzae</i>.

ABSTRACT: Oxalic acid (OA), an essential pathogenic factor, has been identified in several plant pathogens, and researchers are currently pursuing studies on interference with OA metabolism as a treatment for related diseases. However, the metabolic route in Magnaporthe oryzae remains unknown. In this study, we describe D-erythroascorbic acid-mediated OA synthesis and its metabolic and clearance pathways in rice blast fungus. By knocking out the D-arabino-1,4-lactone oxidase gene (Moalo1), one-third of oxalic acid remained in M. oryzae, indicating a main pathway for oxalic acid production. M. oryzae OxdC (MoOxdC) is an oxalate decarboxylase that appears to play a role in relieving oxalic acid toxicity. Loss of Mooxdc does not affect mycelial growth, conidiophore de

SUBMITTER: Liu C 

PROVIDER: S-EPMC11776485 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature