A systematic review of associations between the environment, DNA methylation, and cognition.

ABSTRACT: The increasing prevalence of neurodegenerative diseases poses a significant public health challenge, prompting a growing focus on addressing modifiable risk factors of disease (e.g. physical inactivity, mental illness, and air pollution). The environment is a significant contributor of risk factors which are known to impact the brain and contribute to disease risk (e.g. air pollution, noise pollution, green and blue spaces). Epigenetics can offer insights into how various environmental exposures impact the body to contribute to cognitive outcomes. In this systematic review, we examined studies which have associated an environmental exposure to a type of epigenetic modification, DNA methylation, and a cognitive outcome. We searched four databases with keywords "environmental exposures," "ep

SUBMITTER: Glover S 

PROVIDER: S-EPMC11776599 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature